How The Coronavirus Infects Human Cells | anti inflammatory nutritional supplements
I have noticed that this enzyme is referred to by many as the ACE2 receptor. You should understand that ACE2 is not a receptor, it is an enzyme. The primary function of ACE2 is to convert a pro-inflammatory substance called angiotensin II into anti-inflammatory angiotensin-. Angiotensin II increases blood pressure and also promotes inflammation and lung damage, which is counteracted by angiotensin-, which means we need to produce an adequate amount of angiotensin- to balance the effects of angiotensin II.
This does occur in healthy people, in which a balance is struck between angiotensin II and angiotensin- by the actions of ACE2. Unfortunately, variable degrees of ACE2 deficiency are found in the elderly population, as well as in people with diabetes, hypertension, and heart disease. It turns out that ACE2 can also become glycosylated, which appears to increase the ability of SARS-CoV-2 to infect lung cells . Once a lung cell is infected by SARS-CoV-2, there is a further reduction of ACE2 activity, which further magnifies the imbalance between lung damaging angiotensin II and lung protective angiotensin
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